ERAP1 CLIA Kit for Human(Homo sapiens) | EIAab.comERAP1 CLIA Kit for Human(Homo sapiens)

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Index > Protein center > ERAP1(Gene name) > Human

ERAP1 (Gene name),

Endoplasmic reticulum aminopeptidase 1 (Protein name ), ERAP1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ERAP1(UNQ584/PRO1154;APPILS;ARTS1;KIAA0525);

Protein name:

Endoplasmic reticulum aminopeptidase 1;

Alternative:

Adipocyte-derived leucine aminopeptidase(A-LAP);ARTS-1;Puromycin-insensitive leucyl-specific aminopeptidase(PILS-AP);Aminopeptidase PILS;Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Monomer. May also exist as a heterodimer; with ERAP2. Interacts with RBMX.

Function:

Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.

Subcellular Location:

Endoplasmic reticulum membrane Single-pass type II membrane protein

Protein Attributes:

Sequence length:

941

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

941:

NGSQLRCVQQ | TIETIEENIG | WMDKNFDKIR | VWLQSEKLER | M

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q9NZ08

STRING:

9606.ENSP00000296754

UniGene:

Hs.666524

Pfam:

PF01433

UniGene:

Hs.716426

String:

Q9NZ08

KEGG:

hsa:51752

MIM:

606832

Pfam:

PF11838

Uniprot:

Q9NZ08

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ELISA Kit for Human Endoplasmic reticulum aminopeptidase 1

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E12631h

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96T

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ELISA Kit for Human Endoplasmic reticulum aminopeptidase 1

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E12631r

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96T

ELISA Kit for Human Endoplasmic reticulum aminopeptidase 1

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E12631m

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96T

CLIA Kit for Human Endoplasmic reticulum aminopeptidase 1

Cat.:

U12631h

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Packing:

96T

CLIA Kit for Human Endoplasmic reticulum aminopeptidase 1

Cat.:

U12631m

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MSDS:

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Packing:

96T

CLIA Kit for Human Endoplasmic reticulum aminopeptidase 1

Cat.:

U12631r

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96T

Polyclonal Antibody for Human Endoplasmic reticulum aminopeptidase 1

Cat.:

P12631Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Endoplasmic reticulum aminopeptidase 1

Cat.:

P12631Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Endoplasmic reticulum aminopeptidase 1

Cat.:

P12631Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Endoplasmic reticulum aminopeptidase 1

Protein for Human Endoplasmic reticulum aminopeptidase 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Molecular cloning of adipocyte-derived leucine aminopeptidase highly related to placental leucine aminopeptidase/oxytocinase."
Hattori A. , Matsumoto H. , Mizutani S. , Tsujimoto M.
J. Biochem.125:931-938(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT PRO-127
tissue: White adipose tissue.
2.

"Genomic organization of the human adipocyte-derived leucine aminopeptidase gene and its relationship to the placental leucine aminopeptidase/oxytocinase gene."
Hattori A. , Matsumoto K. , Mizutani S. , Tsujimoto M.
J. Biochem.130:235-241(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);VARIANTS PRO-127; VAL-349; ARG-528; ASN-575; GLN-725 AND GLU-730
tissue: Leukocyte.
3.

"Molecular characterization of human aminopeptidase PILS."
Schomburg L.
Submitted (1999-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS ASP-346; ARG-528 AND GLU-730
4.

"Identification of an aminopeptidase regulator of type I tumor necrosis factor receptor shedding."
Cui X. , Alsaaty S. , Lawrence M. , Combs C.A. , Rouhani F.N. , Levine S.J.
Submitted (2000-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
5.

"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Nagase T. , Ishikawa K. , Miyajima N. , Tanaka A. , Kotani H. , Nomura N. , Ohara O.
DNA Res.5:31-39(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANTS PRO-127; VAL-349; ARG-528; ASN-575; GLN-725 AND GLU-730
tissue: Brain.
6.

"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D. , Okazaki N. , Yamakawa H. , Kikuno R. , Ohara O. , Nagase T.
DNA Res.9:99-106(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
7.

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS PRO-127; VAL-349; ARG-528; ASN-575; GLN-725 AND GLU-730
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Testis.
9.

"Characterization of recombinant human adipocyte-derived leucine aminopeptidase expressed in Chinese hamster ovary cells."
Hattori A. , Kitatani K. , Matsumoto H. , Miyazawa S. , Rogi T. , Tsuruoka N. , Mizutani S. , Natori Y. , Tsujimoto M.
J. Biochem.128:755-762(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 37-49;CHARACTERIZATION
10.

"Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum."
Saveanu L. , Carroll O. , Lindo V. , Del Val M. , Lopez D. , Lepelletier Y. , Greer F. , Schomburg L. , Fruci D. , Niedermann G. , van Endert P.M.
Nat. Immunol.6:689-697(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;SUBUNIT;INDUCTION BY IFNG
11.

"The ER aminopeptidase, ERAP1, trims precursors to lengths of MHC class I peptides by a 'molecular ruler' mechanism."
Chang S.-C. , Momburg F. , Bhutani N. , Goldberg A.L.
Proc. Natl. Acad. Sci. U.S.A.102:17107-17112(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
12.

"An association between RBMX, a heterogeneous nuclear ribonucleoprotein, and ARTS-1 regulates extracellular TNFR1 release."
Adamik B. , Islam A. , Rouhani F.N. , Hawari F.I. , Zhang J. , Levine S.J.
Biochem. Biophys. Res. Commun.371:505-509(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RBMX
13.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-414
tissue: Liver.
14.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
15.

"Crystal structure of the soluble domain of human endoplasmic reticulum aminopeptidase 1 ERAP1."
Structural genomics consortium (SGC)
Submitted (2010-05) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 46-940 IN COMPLEX WITH ZINC IONS;DISULFIDE BONDS;GLYCOSYLATION AT ASN-70; ASN-154 AND ASN-414
16.

"Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1."
Nguyen T.T. , Chang S.C. , Evnouchidou I. , York I.A. , Zikos C. , Rock K.L. , Goldberg A.L. , Stratikos E. , Stern L.J.
Nat. Struct. Mol. Biol.18:604-613(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.95 ANGSTROMS) OF 37-939 IN COMPLEX WITH ZINC IONS AND BESTATIN;FUNCTION;DISULFIDE BONDS;GLYCOSYLATION AT ASN-70; ASN-154 AND ASN-760;ACTIVE SITE;CATALYTIC ACTIVITY;SUBUNIT;MUTAGENESIS OF TYR-438

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